KLRB1 Polyclonal Antibody for Human(Homo sapiens) | EIAab.comKLRB1 Polyclonal Antibody for Human(Homo sapiens)

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KLRB1 (Gene name),

Killer cell lectin-like receptor subfamily B member 1 (Protein name ), KLRB1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

KLRB1(CLEC5B;NKRP1A);

Protein name:

Killer cell lectin-like receptor subfamily B member 1;

Alternative:

HNKR-P1a(NKR-P1A);C-type lectin domain family 5 member B;Natural killer cell surface protein P1A;

CD:

CD161;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer; disulfide-linked. Interacts with acid sphingomyelinase/SMPD1.

Function:

Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.

Subcellular Location:

Membrane Single-pass type II membrane protein

Protein Attributes:

Sequence length:

225

Sequence:

50:

100:

150:

200:

225:

YCSTEIRWIC | QKELTPVRNK | VYPDS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q12918

MIM:

602890

Pfam:

PF00059

UniGene:

Hs.169824

STRING:

9606.ENSP00000229402

String:

Q12918

KEGG:

hsa:3820

Uniprot:

Q12918

FOR

ELISA Kit for Human Killer cell lectin-like receptor subfamily B member 1

Cat.:

E9017h

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96T

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ELISA Kit for Human Killer cell lectin-like receptor subfamily B member 1

Cat.:

E9017m

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Packing:

96T

ELISA Kit for Human Killer cell lectin-like receptor subfamily B member 1

Cat.:

E9017r

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96T

CLIA Kit for Human Killer cell lectin-like receptor subfamily B member 1

Cat.:

U9017h

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Packing:

96T

CLIA Kit for Human Killer cell lectin-like receptor subfamily B member 1

Cat.:

U9017r

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MSDS:

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Packing:

96T

CLIA Kit for Human Killer cell lectin-like receptor subfamily B member 1

Cat.:

U9017m

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Packing:

96T

Polyclonal Antibody for Human Killer cell lectin-like receptor subfamily B member 1

Cat.:

P9017Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Killer cell lectin-like receptor subfamily B member 1

Cat.:

P9017Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Killer cell lectin-like receptor subfamily B member 1

Cat.:

P9017Rb-r

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Killer cell lectin-like receptor subfamily B member 1

Protein for Human Killer cell lectin-like receptor subfamily B member 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Human NKR-P1A: a disulfide-linked homodimer of the C-type lectin superfamily expressed by a subset of NK and T lymphocytes."
Lanier L.L. , Chang C. , Phillips J.H.
J. Immunol.153:2417-2428(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];GLYCOSYLATION;HOMODIMERIZATION;TISSUE SPECIFICITY;FUNCTION
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT THR-168
3.

"IL-12-induced up-regulation of NKRP1A expression in human NK cells and consequent NKRP1A-mediated down-regulation of NK cell activation."
Poggi A. , Costa P. , Tomasello E. , Moretta L.
Eur. J. Immunol.28:1611-1616(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION BY IL12
4.

"CD161+ T (NT) cells exist predominantly in human intestinal epithelium as well as in liver."
Iiai T. , Watanabe H. , Suda T. , Okamoto H. , Abo T. , Hatakeyama K.
Clin. Exp. Immunol.129:92-98(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
5.

"Lectin-like transcript 1 is a ligand for the CD161 receptor."
Aldemir H. , Prod'homme V. , Dumaurier M.-J. , Retiere C. , Poupon G. , Cazareth J. , Bihl F. , Braud V.M.
J. Immunol.175:7791-7795(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CLEC2D
6.

"Lectin-like transcript-1 is a ligand for the inhibitory human NKR-P1A receptor."
Rosen D.B. , Bettadapura J. , Alsharifi M. , Mathew P.A. , Warren H.S. , Lanier L.L.
J. Immunol.175:7796-7799(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CLEC2D
7.

"CD161 (human NKR-P1A) signaling in NK cells involves the activation of acid sphingomyelinase."
Pozo D. , Vales-Gomez M. , Mavaddat N. , Williamson S.C. , Chisholm S.E. , Reyburn H.
J. Immunol.176:2397-2406(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SMPD1
8.

"Recognition of a carbohydrate xenoepitope by human NKRP1A (CD161)."
Christiansen D. , Mouhtouris E. , Milland J. , Zingoni A. , Santoni A. , Sandrin M.S.
Xenotransplantation13:440-446(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS A LECTIN
9.

"Characterization of alternatively spliced transcript variants of CLEC2D gene."
Germain C. , Bihl F. , Zahn S. , Poupon G. , Dumaurier M.J. , Rampanarivo H.H. , Padkjaer S.B. , Spee P. , Braud V.M.
J. Biol. Chem.285:36207-36215(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CLEC2D

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